Malic Acid
![Medchemexpress LLC 3-[4-(4-hydroxyphenyl)piperazin-1-yl]-1-phenylpyrrolidine-2,5-dione | 522649-59-8 | 99.7% | 351.4 g/mol | C20H21N3O3 | 10MM 1ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000238829.png-250.jpg)
Medchemexpress LLC 3-[4-(4-hydroxyphenyl)piperazin-1-yl]-1-phenylpyrrolidine-2,5-dione | 522649-59-8 | 99.7% | 351.4 g/mol | C20H21N3O3 | 10MM 1ML
Malic enzyme inhibitor ME1 is a small-molecule research reagent that inhibits cytosolic malic enzyme 1 (ME1) with a reported IC50 of 0.15 μM. The compound is supplied in ready-to-use solution formats for in vitro assays and is provided with supporting documentation for safe handling and quality verification.
- Potent ME1 inhibitor (IC50 0.15 μM).
- Supplied as 10 mM solution in DMSO, ready for in vitro use.
- High purity (≈99.7%) with certificate of analysis available.
- Soluble in DMSO up to 100 mg/mL; warming can improve solubility.
- Storage stability information provided for powder and solution formats.
- Documentation includes SDS, COA, and product data sheet for handling and quality details.
![Medchemexpress LLC Butanedioic acid, 2-hydroxy-, (2S)-, compd. with (3S)-1-azabicyclo[2.2.2]oct-3-yl N-[1-[2-(4-fluorophenyl)-4-thiazolyl]-1-methylethyl]carbamate (1:1) | 1629063-78-0 | 98.65% | 523.57 | 2 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000390778.png-250.jpg)
Medchemexpress LLC Butanedioic acid, 2-hydroxy-, (2S)-, compd. with (3S)-1-azabicyclo[2.2.2]oct-3-yl N-[1-[2-(4-fluorophenyl)-4-thiazolyl]-1-methylethyl]carbamate (1:1) | 1629063-78-0 | 98.65% | 523.57 | 2 MG
Ibiglustat (L-Malic acid) is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. It can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease. It can prevent additional GL-3 accumulation and could ameliorate the abundant levels of sphingolipid in FD cardiomyocytes.
- Orally active
- Brain-penetrant
- Glucosylceramide synthase (GCS) inhibitor
- Soluble in DMSO (≥ 100 mg/mL, 191.00 mM)
- Can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease
Medchemexpress LLC (S)-Malic acid | 97-67-6 | MFCD00064213 | 99.6% | 134.09 g/mol | C4H6O5 | 25mg
(S)-Malic acid (Standard) is the analytical standard of (S)-Malic acid This product is intended for research and analytical applications (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form contributes to the pleasantly sour taste of fruits and is used as a food additive In Vitro It is showed that ME is essential for (S)-2-Hydroxysuccinic acid (L-malic acid) utilization in L casei Furthermore deletion of either the gene encoding the histidine kinase or the response regulator of the TC system resulted in the loss of the ability to grow on (S)-2-Hydroxysuccinic acid thus indicating that the cognate TC system regulates and is essential for the expression of ME Transcriptional analyses shows that expression of maeE is induced in the presence of (S)-2-Hydroxysuccinic acid and repressed by glucose whereas TC system expression is induced by (S)-2-Hydroxysuccinic acid and is not repressed by glucose[1]
Medchemexpress LLC D-Malic acid | 636-61-3 | MFCD00004245 | 134.09 g/mol | 100 MG
D-Malic acid, also known as (R)-malic acid, is an optically active form of malic acid with an (R)-configuration. It acts as a conjugate acid of (R)-malate(2-) and is the enantiomer of (S)-malic acid. It has been identified as a metabolite in organisms such as Escherichia coli (strain K12, MG1655), Vaccinium macrocarpon, and Arabidopsis thaliana.
- Optically active form of malic acid with (R)-configuration
- Conjugate acid of (R)-malate(2-)
- Enantiomer of (S)-malic acid
- Primary hazards include corrosive and irritant properties
- Utilized as an intermediate, chelating agent, buffering agent, and food additive
- Identified in Escherichia coli, Vaccinium macrocarpon, and Arabidopsis thaliana
Medchemexpress LLC (S)-Malic acid | 97-67-6 | MFCD00064213 | 134.09 g/mol | C4H6O5 | 1mL
(S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form contributes to the pleasantly sour taste of fruits and is used as a food additive
Sigma Aldrich Fine Chemicals Biosciences L Malic acid BioReagent500G
Malic acid is used as a component of insect tissue culture. It is also useful as an acidulant in soft drinks jams fruit and vegetable juices.
Medchemexpress LLC Malic acid disodium hydrate | 63474-37-3 | 98.0% | 178.05 g/mol | C4H6O5·xH2O·2Na | 10 G
Malic acid disodium hydrate is the disodium salt of malic acid, supplied as a solid reagent used as a buffering agent and biochemical assay reagent. It dissolves readily in water and is commonly used to prepare buffers, control pH in assays, and as an acidity regulator in formulation work.
- High water solubility for easy dissolution.
- Useful for buffer preparation and pH control in biochemical assays.
- Serves as an acidity regulator and ingredient in formulation studies.
- Approximately 98.0% purity suitable for laboratory use.
- Packaged for convenient handling and storage.
Medchemexpress LLC Ibiglustat (L-malic acid) | 1629063-78-0 | MFCD31746910 | 523.57 g/mol | C24H30FN3O7S | 10 MG
Ibiglustat (L-malic acid) is the L-malate salt of ibiglustat (venglustat), an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor supplied as a powder for research use. It is intended for in vitro and preclinical studies of lysosomal storage disorders and GBA-associated neurological disease. Key chemical identifiers include CAS 1629063-78-0, formula C24H30FN3O7S, and molecular weight 523.57 g/mol.
- Powder form suitable for preparation of stock solutions.
- L-malate salt improves handling and solubility properties.
- Brain-penetrant GCS inhibitor for CNS disease research.
- High DMSO solubility (≥ 100 mg/mL) for convenient stock preparation.
- Stable as powder at -20°C for long-term storage; solvent stability varies by temperature.
- Chemical identifiers provided for unambiguous compound identification.
Medchemexpress LLC DL-malic acid | 6915-15-7 | MFCD00064212 | 134.09 g/mol | C4H6O5 | 50g
Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that occurs naturally in fruits like apples and pears with oral activities Malic acid plays a role in many sour or tangy foods Malic acid is an intermediate in the citric acid cycle[1][2]
Medchemexpress LLC (S)-malic acid | 97-67-6 | MFCD00064212 | 95.8% | 134.09 g/mol | C4H6O5 | 10g
(S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form contributes to the pleasantly sour taste of fruits and is used as a food additive
Medchemexpress LLC (S)-malic acid | 97-67-6 | MFCD00064213 | 134.09 g/mol | C4H6O5 | 25g
(S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form contributes to the pleasantly sour taste of fruits and is used as a food additive
Medchemexpress LLC Malic acid (standard) | 6915-15-7 | MFCD00064212 | 99.8% | 134.09 g/mol | C4H6O5 | 25mg
Malic acid (Standard) is the analytical standard of Malic acid This product is intended for research and analytical applications Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears It plays a role in many sour or tart foods
Medchemexpress LLC (S)-malic acid | 97-67-6 | MFCD00064212 | 99.6% | 134.09 g/mol | C4H6O5 | 500mg
(S)-Malic acid (Standard) is the analytical standard of (S)-Malic acid This product is intended for research and analytical applications (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form contributes to the pleasantly sour taste of fruits and is used as a food additive In Vitro It is showed that ME is essential for (S)-2-Hydroxysuccinic acid (L-malic acid) utilization in L casei Furthermore deletion of either the gene encoding the histidine kinase or the response regulator of the TC system resulted in the loss of the ability to grow on (S)-2-Hydroxysuccinic acid thus indicating that the cognate TC system regulates and is essential for the expression of ME Transcriptional analyses shows that expression of maeE is induced in the presence of (S)-2-Hydroxysuccinic acid and repressed by glucose whereas TC system expression is induced by (S)-2-Hydroxysuccinic acid and is not repressed by glucose[1]